|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that body weight loss upregulates the expression of Mfn2 mRNA in skeletal muscle of obese humans, type 2 diabetes downregulates the expression of Mfn2 mRNA in skeletal muscle, Mfn2 expression in skeletal muscle is directly proportional to insulin sensitivity and is inversely proportional to the BMI, TNFalpha and interleukin-6 downregulate Mfn2 expression and may participate in the dysregulation of Mfn2 expression in obesity or type 2 diabetes, and the in vivo modulation of Mfn2 mRNA levels is an additional level of regulation for the control of muscle metabolism and could provide a molecular mechanism for alterations in mitochondrial function in obesity or type 2 diabetes.
|
16123358 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines.
|
22607892 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα); increased stem cell recruitment (Oct-4, Sox-2) and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation); accelerated preadipocyte induction (Dact-1, PPARγ2) with a quantitative increase in mature adipocyte formation (Leptin); ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants.
|
23144726 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adoptive transfer experiments of cytokine-deficient mast cells show that these cells, by producing interleukin-6 (IL-6) and interferon-gamma (IFN-gamma), contribute to mouse adipose tissue cysteine protease cathepsin expression, apoptosis and angiogenesis, thereby promoting diet-induced obesity and glucose intolerance.
|
19633655 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this cohort, mean (SD) habitual sleep duration based on self-report was 7.6 (1.6) h and mean sleep duration by polysomnography (PSG) on the night prior to blood sampling was 6.2 (1.3) h. After adjusting for obesity and apnea severity, each additional hour of habitual sleep duration was associated with an 8% increase in C-reactive protein (CRP) levels (P=0.004) and 7% increase in interleukin-6 (IL-6) levels (P=0.0003).
|
19238807 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Haptoglobin 2-2 genotype is associated with TNF- α and IL-6 levels in subjects with obesity.
|
24868113 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT.
|
27083404 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In patients with chronic HCV, obesity and steatosis are associated with increased expression of selected inflammatory markers; however, circulating levels of IL-6 and TNF-alpha do not reflect hepatic expression.
|
18571785 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT.
|
31533725 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, levels of IL-6 in cerebrospinal fluid (CSF) were reported to be inversely correlated with obesity in humans.
|
29024103 |
2017 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05).
|
31365708 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression of CD31, eNOS phosphorylation and NO were increased; the reduction of local neutrophils influx, ICAM-1 and IL-6/8 expression levels were obvious especially in diabetic with obesity rats at d10 after Wnt7a treatment.
|
29853224 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, SP-D deficiency worsened hypercholesterolemia and induced obesity and insulin resistance but suppressed plasma interleukin-6 (IL-6) levels.
|
28472244 |
2017 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our findings show that although pre-gravid obesity was associated with greater expression of placental pro-inflammatory cytokines and higher circulating IL-6 in pregnancy, there were no major differences in immune cell populations within the placental villi and only a greater degree of muscularity in the vessel walls.
|
21232790 |
2011 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further, interventions that target both obesity and elevated levels of IL-6 are likely to be more effective than those focusing on only one.
|
29795469 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity was associated with high IL-6 levels (SC = 0.232, P = 0.001).
|
29342369 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production.
|
25476497 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating levels of interleukin-6 (IL-6) are raised in insulin resistant states such as obesity, impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM).
|
15172007 |
2004 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Studies including a complete evaluation of inflammatory markers are scarce and high levels of interleukin-6 (IL-6) and C-reactive protein (CRP) are the most consistent findings associated with obesity and symptoms of depression.
|
29550676 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of IL-6 increase with obesity and insulin resistance.
|
19428338 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Data suggest that decreased serum level of IL-6 following antipsychotic therapy could be predisposing factor for the development of obesity and obesity-related metabolic disorders in schizophrenia.
|
29163240 |
2017 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects.
|
30904536 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in visceral fat tissues.
|
28196859 |
2017 |